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KMID : 0043319930160040339
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Archives of Pharmacal Research
1993 Volume.16 No. 4 p.339 ~ p.342
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Antiviral Activity of Triterpenoid Derivatives
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Ryu Shi-Yong
Lee Chong-Kyo
Ahn Jong-Woong
Lee Seung-Ho
Zee Ok-Pyo
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Abstract
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3-Oxo or/and 11-oxo derivatives of natural 3-hydroxy triterpense, i.e., 3-oxoursolic acid la, 11-oxoursolic acid lb, 3, 11-dioxoursolic acid ic, 3-oxobetulinic acid lla and 3-oxopomolic acid Via were exhibited to show an increased anti-HSV-1 activity in vitro, four to ten times as much as corresponding parent 3-hydroxy compounds.
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KEYWORD
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3-Oxoursolic acid, 3-Oxobetulinic acid, 11-Oxoursolic acid, 3-Oxopomolic acid, 3, 11-Dioxoursolic acid, 3-Oxoglycyrthetinic acid, Antiviral, HSV-1
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